منابع مشابه
Response modification in carcinogenesis.
A major goal in multistep carcinogenesis research is the integration of recent findings obtained by sophisticated molecular-genetic and cytogenetic analysis of cancer into the more descriptive concepts of experimental pathology. It is proposed that the creation of a promotable cell in carcinogenic initiation requires a response modification to extracellular or intercellular signals. Different t...
متن کاملDose-response relationship in multistage carcinogenesis: promoters.
Published dose-response curves of promoters of multistage carcinogenesis were selected that met the combined criteria of long study times, multiple doses, and low doses. In rat liver, 12 dose-response studies of 7 different promoters (phenobarbital, 2,3,7,8-tetrachlorodibenzo-p-dioxin [TCDD], clophen A-50 (a polychlorinated biphenyl), alpha-, beta-, and gamma-hexachlorocyclohexane [HCH], and ch...
متن کاملResponse Modification Factor of Coupled Steel Shear Walls
The present research is concerned with the determination of ductility, over-strength and response modification factors of coupled steel shear wall frames. Three structural models with various numbers of stories, bay width and coupling beam height were analyzed using static pushover and incremental nonlinear dynamic analyses. The ductility, over-strength and response modification factors for the...
متن کاملEvaluating Response Modification Factors of Concentrically Braced and Special Moment Steel Frames in Duplex Buildings
Response modification factor (R-factor) is one of the seismic design parameters to consider nonlinear performance of building structures during strong earthquake. Relying on this, many seismic design codes led to reduce earthquake loads imposed to the structure. The present paper tries to evaluate the R-factors of conventional concentric braced frames (CBFs) and special moment frames (MRFs) in ...
متن کاملThe Chemokine CXCL8 in Carcinogenesis and Drug Response
Although the functions of chemokines in the regulation of immune processes have been studied in some detail, the role of these biomolecules in cancer is not fully understood. Chemokines mediate migration of immune cells and other functions related to immunity. They are also involved in oncogenesis and in tumor progression, invasion, and metastasis through mechanisms similar to their roles in im...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1989
ISSN: 0091-6765
DOI: 10.2307/3430802